Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.4636 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1869 | 0.2092 | 0.1534 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.3449 | 0.6607 | 0.571 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.1583 | 0.1273 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.3449 | 0.6607 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.3449 | 0.6607 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1869 | 0.2092 | 0.1534 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.4636 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.3449 | 0.6607 | 0.6607 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.1583 | 0.1273 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.4636 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1869 | 0.2092 | 0.1534 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1869 | 0.2092 | 0.2092 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1869 | 0.2092 | 0.1534 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.4636 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.3449 | 0.6607 | 0.571 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.4636 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.3449 | 0.6607 | 0.571 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.3449 | 0.6607 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3449 | 0.6607 | 0.6607 |
Trypanosoma cruzi | prolyl endopeptidase | 0.3449 | 0.6607 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.3449 | 0.6607 | 0.571 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.2773 | 0.4676 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1869 | 0.2092 | 0.1534 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.