Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0076 | 0.051 | 0.0784 |
Echinococcus granulosus | prolyl endopeptidase | 0.0154 | 0.6507 | 0.632 |
Toxoplasma gondii | prolyl endopeptidase | 0.0154 | 0.6507 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0154 | 0.6507 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0199 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0154 | 0.6507 | 0.632 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0154 | 0.6507 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0154 | 0.6507 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0199 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0199 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0154 | 0.6507 | 0.632 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.007 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0076 | 0.051 | 0.0784 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0154 | 0.6507 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0199 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0076 | 0.051 | 0.0784 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.007 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0076 | 0.051 | 0.0784 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0076 | 0.051 | 0.0784 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0124 | 0.4241 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0154 | 0.6507 | 0.632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.