Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0209 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0209 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0209 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0209 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.009 | 0 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.009 | 0 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0209 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0209 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0209 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0209 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0209 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0209 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.