Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.3303 | 0.6973 | 0.6147 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.4281 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.4281 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1743 | 0.2145 | 0.1307 |
Echinococcus granulosus | prolyl endopeptidase | 0.3303 | 0.6973 | 0.6147 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.3303 | 0.6973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3303 | 0.6973 | 0.6973 |
Trypanosoma cruzi | prolyl endopeptidase | 0.3303 | 0.6973 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.3303 | 0.6973 | 0.6147 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.2667 | 0.5004 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1743 | 0.2145 | 0.1307 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.3303 | 0.6973 | 0.6147 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.4281 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1743 | 0.2145 | 0.1307 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1743 | 0.2145 | 0.1307 |
Trypanosoma brucei | prolyl endopeptidase | 0.3303 | 0.6973 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.3303 | 0.6973 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.1509 | 0.142 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.4281 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.3303 | 0.6973 | 0.6973 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1743 | 0.2145 | 0.1307 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1743 | 0.2145 | 0.2145 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.1509 | 0.142 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.4281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4654 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.