Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1716 | 0.8756 | 0.8756 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1897 | 1 | 1 |
Leishmania major | oligopeptidase b | 0.0765 | 0.2206 | 0.018 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.1413 | 0.667 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1897 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0765 | 0.2206 | 0.018 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.1716 | 0.8756 | 0.8428 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0765 | 0.2206 | 0.018 |
Trypanosoma brucei | oligopeptidase b | 0.0765 | 0.2206 | 0.018 |
Toxoplasma gondii | prolyl endopeptidase | 0.1716 | 0.8756 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0765 | 0.2206 | 0.018 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.1716 | 0.8756 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0765 | 0.2206 | 0.018 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0765 | 0.2206 | 0.018 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0765 | 0.2206 | 0.018 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0765 | 0.2206 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.1716 | 0.8756 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0765 | 0.2206 | 0.018 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0748 | 0.2086 | 0.2086 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0765 | 0.2206 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1716 | 0.8756 | 0.8756 |
Echinococcus granulosus | prolyl endopeptidase | 0.1716 | 0.8756 | 0.8428 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1897 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.1716 | 0.8756 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.1716 | 0.8756 | 0.8428 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1897 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1897 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.1716 | 0.8756 | 0.8428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.