Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2378 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1021 | 0.3028 | 0.0831 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.2057 | 0.835 | 0.7634 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.0806 | 0.0806 |
Toxoplasma gondii | prolyl endopeptidase | 0.2057 | 0.835 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.2057 | 0.835 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0927 | 0.2545 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1021 | 0.3028 | 0.0831 |
Brugia malayi | prolyl oligopeptidase family protein | 0.2057 | 0.835 | 0.8206 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2378 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0927 | 0.2545 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2378 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1021 | 0.3028 | 0.2417 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1021 | 0.3028 | 0.0831 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1021 | 0.3028 | 0.0831 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2378 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.2057 | 0.835 | 0.7634 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2378 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.2057 | 0.835 | 0.7634 |
Loa Loa (eye worm) | hypothetical protein | 0.2057 | 0.835 | 0.835 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.2057 | 0.835 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.2057 | 0.835 | 0.7634 |
Trypanosoma cruzi | prolyl endopeptidase | 0.2057 | 0.835 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.1678 | 0.6406 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1021 | 0.3028 | 0.0831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 80 uM | PubChem BioAssay. Dose response counterscreen for EBI2 assay utilizing the enzyme, b-galactosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.