Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0609 | 0.2333 | 0.5895 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0609 | 0.2333 | 0.5895 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0772 | 0.3958 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0772 | 0.3958 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0772 | 0.3958 | 0.2119 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0609 | 0.2333 | 0.5895 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1378 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0772 | 0.3958 | 0.2119 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0772 | 0.3958 | 0.2119 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1378 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.059 | 0.2137 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0375 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0375 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1378 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0772 | 0.3958 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1378 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0609 | 0.2333 | 0.5895 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0772 | 0.3958 | 0.2119 |
Trypanosoma brucei | prolyl endopeptidase | 0.0772 | 0.3958 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0772 | 0.3958 | 0.2119 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0609 | 0.2333 | 0.5895 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1378 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.