Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | No references |
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0043 | 0.185 | 0.185 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.7527 | 0.7527 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.7527 | 0.7527 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.185 | 0.5 |
Brugia malayi | Phospholipase d protein 1 | 0.0124 | 0.9377 | 0.9377 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0043 | 0.185 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.9377 | 1 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 0.9377 | 0.9377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0043 | 0.185 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.5346 | 0.5346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase D | 0.011 | 0.8028 | 0.8028 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.5346 | 0.5346 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 1 | 1 |
Trypanosoma brucei | cardiolipin synthetase | 0.0043 | 0.185 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 1 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.185 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0131 | 1 | 1 |
Onchocerca volvulus | Putative phospholipase D | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.9377 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 1 | 1 |
Echinococcus granulosus | phospholipase D | 0.011 | 0.8028 | 0.8028 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 0.9377 | 0.9377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.5 uM | PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 1.9 uM | PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.