Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0068 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0068 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0149 | 0.3172 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1339 | 0.2235 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0068 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.3172 | 0.5295 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0103 | 0.1339 | 0.4221 |
Loa Loa (eye worm) | RNA binding protein | 0.0149 | 0.3172 | 0.3172 |
Loa Loa (eye worm) | TAR-binding protein | 0.0149 | 0.3172 | 0.3172 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1339 | 0.2235 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.3172 | 0.5295 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5991 | 0.5991 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1339 | 0.2235 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0103 | 0.1339 | 0.4221 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0103 | 0.1339 | 0.1339 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.3172 | 0.5295 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0068 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0149 | 0.3172 | 0.3172 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0221 | 0.5991 | 0.5991 |
Echinococcus multilocularis | tar DNA binding protein | 0.0149 | 0.3172 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1339 | 0.1339 |
Echinococcus multilocularis | GPCR, family 2 | 0.0103 | 0.1339 | 0.4221 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0103 | 0.1339 | 0.4221 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0103 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0149 | 0.3172 | 0.3172 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0068 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0149 | 0.3172 | 0.3172 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1339 | 0.2235 |
Echinococcus granulosus | GPCR family 2 | 0.0103 | 0.1339 | 0.4221 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0324 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0103 | 0.1339 | 0.4221 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.3172 | 0.5295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.3172 | 0.5295 |
Brugia malayi | RNA binding protein | 0.0149 | 0.3172 | 0.3172 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0221 | 0.5991 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0103 | 0.1339 | 0.1339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 5.1 mg kg-1 | Compound was tested for oral efficacy on systemic infections on mice by peroral administration | ChEMBL. | 8064806 |
ED50 (functional) | = 5.1 mg kg-1 | Compound was tested for oral efficacy on systemic infections on mice by peroral administration | ChEMBL. | 8064806 |
MIC (functional) | = 0.006 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-positive microorganism S. aureus IID 803 (Sa(I)) | ChEMBL. | 8064806 |
MIC (functional) | <= 0.006 ug ml-1 | Tested for in vitro for antibacterial activity against 16 clinical isolated of methicillin-resistant Staphylococcus aureus, range of Minimal inhibitory activity value for isolates | ChEMBL. | 8064806 |
MIC (functional) | = 0.0125 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-positive microorganism Staphylococcus aureus FDA 209P JC-1 (Sa(F)) | ChEMBL. | 8064806 |
MIC (functional) | = 0.05 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-positive microorganism S. epidermis IAM 1296 (Se) | ChEMBL. | 8064806 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-positive microorganism E. faecalis IID682 (Ef) | ChEMBL. | 8064806 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism E. coli NIHJ JC-2 (Ec(N)) | ChEMBL. | 8064806 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism E. coli KC-14 (Ec(K)) | ChEMBL. | 8064806 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism E. coli NIHJ JC-2 (Ec(N)) | ChEMBL. | 8064806 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism E. coli KC-14 (Ec(K)) | ChEMBL. | 8064806 |
MIC (functional) | = 0.2 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-positive microorganism M. luteus ATCC 9341 (MI) | ChEMBL. | 8064806 |
MIC (functional) | = 0.39 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism K. pneumoniae B54 (Kp) | ChEMBL. | 8064806 |
MIC (functional) | = 1.56 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism P. aeruginosa IFO 3445 (Pa(I)) | ChEMBL. | 8064806 |
MIC (functional) | = 1.56 ug ml-1 | Compound was tested for its minimal inhibitory constant against Gram-negative microorganism P. aeruginosa E-2 (Pa(E)) | ChEMBL. | 8064806 |
MIC50 (functional) | = 0.39 ug ml-1 | Tested for in vitro for antibacterial activity against 16 clinical isolated of methicillin-resistant Staphylococcus aureus | ChEMBL. | 8064806 |
MIC90 (functional) | = 0.78 ug ml-1 | Tested for in vitro for antibacterial activity against 16 clinical isolated of methicillin-resistant Staphylococcus aureus | ChEMBL. | 8064806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.