Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0117 | 0.3312 | 0.2758 |
Brugia malayi | CHE-14 protein | 0.005 | 0.0865 | 0.2533 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3312 | 0.3289 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0027 | 0 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0117 | 0.3312 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.6307 | 0.6294 |
Schistosoma mansoni | patched 1 | 0.005 | 0.0865 | 0.0126 |
Echinococcus granulosus | expressed conserved protein | 0.011 | 0.3052 | 0.5102 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0168 | 0.5152 | 0.4831 |
Echinococcus multilocularis | protein dispatched 1 | 0.0057 | 0.1125 | 0.0293 |
Echinococcus multilocularis | expressed conserved protein | 0.011 | 0.3052 | 0.2465 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0117 | 0.3312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0865 | 0.0833 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0119 | 0.3378 | 0.4917 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0293 | 0.9739 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.9025 | 0.9021 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1279 | 0.1248 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0192 | 0.6046 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0168 | 0.5152 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.005 | 0.0865 | 0.0833 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0117 | 0.3312 | 0.5709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.