Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kringle domain containing protein | 0.0055 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0055 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0055 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0033 | 0.2772 | 0.2772 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0055 | 1 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.1058 | 0.1058 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.1058 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1058 | 0.1058 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0055 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.1058 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1058 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.1058 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1058 | 0.5 |
Onchocerca volvulus | 0.0055 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1058 | 0.1058 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.1058 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1058 | 0.1058 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.1058 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1058 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1058 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1058 | 0.1058 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1058 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.1058 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1058 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1058 | 0.1058 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0029 | 0.1306 | 0.1306 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.1058 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1058 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0055 | 1 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.1058 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.99 uM | Cytotoxicity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay | ChEMBL. | 21443218 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21443218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.