Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0071 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0071 | 0 | 0.5 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.7641 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1977 | 1 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1977 | 1 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.25 nM | Inhibitory activity against HIV Protease in peptide cleavage assay | ChEMBL. | 1910089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.