Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0355 | 0.5 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0355 | 0.5 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0355 | 0.5 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Giardia lamblia | CDC8 | 0.0355 | 0.5 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0355 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.0355 | 0.5 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.5 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0355 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 2.6 nM | Antagonist potency against human histamine H3 receptor expressed in CHO cells was determined by GTPgamma[S]-assay | ChEMBL. | 15139761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.