TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.939 | Formula: C18H18ClF3N4O3S2
H donors: 4 H acceptors: 2 LogP: 3.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1ccc(c(c1)C(F)(F)F)Cl)NC[C@H]1O[C@@H](C[C@@H]1O)n1cc(C)c(=S)[nH]c1=O
InChi: 1S/C18H18ClF3N4O3S2/c1-8-7-26(17(28)25-15(8)30)14-5-12(27)13(29-14)6-23-16(31)24-9-2-3-11(19)10(4-9)18(20,21)22/h2-4,7,12-14,27H,5-6H2,1H3,(H2,23,24,31)(H,25,28,30)/t12-,13+,14-/m0/s1
InChiKey: ZOSAVGSYBNMSTG-MJBXVCDLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania braziliensis	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Giardia lamblia	CDC8	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma cruzi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium vivax	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium knowlesi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trichomonas vaginalis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	Get druggable targets OG5_126920	All targets in OG5_126920
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania infantum	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Echinococcus multilocularis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma japonicum	Thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Theileria parva	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium ulcerans	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Echinococcus granulosus	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Candida albicans	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium falciparum	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Candida albicans	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma congolense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Neospora caninum	Thymidylate kinase, related	Get druggable targets OG5_126920	All targets in OG5_126920
Babesia bovis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Treponema pallidum	thymidylate kinase (tmk)	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei gambiense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma cruzi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma congolense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Cryptosporidium parvum	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Toxoplasma gondii	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania mexicana	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Trichomonas vaginalis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Cryptosporidium hominis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Chlamydia trachomatis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania major	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Loa Loa (eye worm)	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma japonicum	ko:K00943 dTMP kinase [EC2.7.4.9], putative	Get druggable targets OG5_126920	All targets in OG5_126920
Entamoeba histolytica	Thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium yoelii	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Onchocerca volvulus	Putative thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania donovani	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium berghei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126920	All targets in OG5_126920

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0013	0.00000034796	0.00000035021
Loa Loa (eye worm)	hypothetical protein	0.0013	0.00000034796	0.00000034796
Onchocerca volvulus	Putative thymidylate kinase	0.0087	0.2715	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Brugia malayi	Uncoordinated protein 44	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	cask-interacting protein (caskin) 1,2, putative	0.0013	0.00000034796	0.00000035021
Leishmania major	thymidylate kinase-like protein	0.0087	0.2715	1
Echinococcus multilocularis	thymidylate kinase	0.0087	0.2715	0.2715
Echinococcus multilocularis	Ankyrin	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat and sam domain-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ion channel nompc, putative	0.0013	0.00000034796	0.00000035021
Entamoeba histolytica	Thymidylate kinase, putative	0.0087	0.2715	0.2715
Schistosoma mansoni	thymidylate kinase	0.0087	0.2715	0.2715
Giardia lamblia	Kinase, NEK-frag	0.0015	0.0064	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	nf kappa B inhibitor I-kappa-B, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	homeobox-containing protein wariai, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Chlamydia trachomatis	thymidylate kinase	0.0087	0.2715	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Brugia malayi	Patatin-like phospholipase family protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.2715	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Echinococcus granulosus	26S proteasome non ATPase regulatory subunit 10	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Schistosoma mansoni	ankyrin 23/unc44	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	inversin, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	cortactin-binding protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Giardia lamblia	Protein 21.1	0.0013	0.00000034796	0.0000012815
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0013	0.00000034796	0.00000035021
Echinococcus granulosus	thymidylate kinase	0.0087	0.2715	0.2715
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Loa Loa (eye worm)	hypothetical protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Schistosoma mansoni	thymidylate kinase	0.0087	0.2715	0.2715
Trichomonas vaginalis	ion channel nompc, putative	0.0013	0.00000034796	0.00000035021
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0087	0.2715	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0013	0.00000034796	0.00000035021
Loa Loa (eye worm)	IRE protein kinase	0.0284	1	1
Schistosoma mansoni	phospholipase	0.0013	0.00000034796	0.00000034796
Brugia malayi	Leucine Rich Repeat family protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Loa Loa (eye worm)	tnks protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0147	0.0148
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.2715	0.2733
Echinococcus granulosus	Ankyrin	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	TKL family protein kinase	0.0015	0.0064	0.0065
Plasmodium vivax	thymidylate kinase, putative	0.0087	0.2715	0.5
Echinococcus multilocularis	ankyrin repeat domain containing protein 6	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	fibronectin type 3 and ankyrin repeat domains, putative	0.0013	0.00000034796	0.00000035021
Entamoeba histolytica	ankyrin repeat protein, putative	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	26S proteasome non-ATPase regulatory subunit, putative	0.0013	0.00000034796	0.00000035021
Giardia lamblia	Kinase, NEK	0.0015	0.0064	0.0236
Echinococcus granulosus	Ankyrin	0.0013	0.00000034796	0.00000034796
Giardia lamblia	CDC8	0.0087	0.2715	1
Trichomonas vaginalis	E3 ubiquitin protein ligase, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0013	0.00000034796	0.00000035021
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0034	0.0766	0.282
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0013	0.00000034796	0.00000035021
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0087	0.2715	0.5
Trichomonas vaginalis	ankyrin, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0013	0.00000034796	0.00000035021
Giardia lamblia	Ankyrin 1	0.0013	0.00000034796	0.0000012815
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0013	0.00000034796	0.00000035021
Giardia lamblia	Protein 21.1	0.0013	0.00000034796	0.0000012815
Plasmodium falciparum	thymidylate kinase	0.0087	0.2715	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Leishmania major	hypothetical protein, conserved	0.0013	0.00000034796	0.0000012815
Giardia lamblia	Kinase, NEK	0.0015	0.0064	0.0236
Brugia malayi	thymidylate kinase	0.0087	0.2715	0.2715
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ion channel nompc, putative	0.0013	0.00000034796	0.00000035021
Echinococcus multilocularis	Ankyrin	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0283	0.9936	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Leishmania major	hypothetical protein, conserved	0.0034	0.0766	0.282
Schistosoma mansoni	serine/threonine protein kinase	0.0284	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	rolling pebbles, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0013	0.00000034796	0.00000035021
Schistosoma mansoni	tankyrase	0.0013	0.00000034796	0.00000034796
Echinococcus multilocularis	tankyrase	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0013	0.00000034796	0.00000035021
Mycobacterium ulcerans	thymidylate kinase	0.0087	0.2715	0.5
Loa Loa (eye worm)	thymidylate kinase	0.0087	0.2715	0.2715
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.2715	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin, putative	0.0013	0.00000034796	0.00000035021
Echinococcus granulosus	tankyrase	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0013	0.00000034796	0.00000035021
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.2715	1
Trypanosoma brucei	Ankyrin repeats (many copies), putative	0.0013	0.00000034796	0.0000012815
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0013	0.00000034796	0.00000035021
Schistosoma mansoni	26S proteasome subunit	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat domain-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Schistosoma mansoni	hypothetical protein	0.0087	0.2715	0.2715
Trypanosoma cruzi	ankyrin repeat protein, putative	0.0013	0.00000034796	0.0000012815
Trichomonas vaginalis	ankyrin, putative	0.0013	0.00000034796	0.00000035021
Echinococcus multilocularis	26S proteasome non ATPase regulatory subunit 10	0.0013	0.00000034796	0.00000034796
Toxoplasma gondii	thymidylate kinase	0.0087	0.2715	1
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0087	0.2715	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.2715	0.2733
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.2715	1
Trichomonas vaginalis	ankyrin, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0013	0.00000034796	0.00000035021
Entamoeba histolytica	protein kinase, putative	0.0284	1	1
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0034	0.0766	0.282
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0017	0.0147	0.0148
Schistosoma mansoni	ga binding protein beta chain (transcription factor e4tf1-47)	0.0013	0.00000034796	0.00000034796
Giardia lamblia	Kinase, NEK	0.0015	0.0064	0.0236
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0013	0.00000034796	0.00000035021
Entamoeba histolytica	protein kinase, putative	0.0284	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0284	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0283	0.9936	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0013	0.00000034796	0.00000035021
Brugia malayi	Patatin-like phospholipase family protein	0.0013	0.00000034796	0.00000034796
Treponema pallidum	thymidylate kinase (tmk)	0.0087	0.2715	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	mind bomb, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0013	0.00000034796	0.00000035021
Loa Loa (eye worm)	hypothetical protein	0.0013	0.00000034796	0.00000034796
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0017	0.0147	0.0148
Giardia lamblia	Kinase, NEK	0.0015	0.0064	0.0236
Leishmania major	ankyrin/TPR repeat protein	0.0013	0.00000034796	0.0000012815
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0013	0.00000034796	0.00000035021
Trichomonas vaginalis	tankyrase, putative	0.0013	0.00000034796	0.00000035021
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0284	1	1
Trichomonas vaginalis	ion channel nompc, putative	0.0013	0.00000034796	0.00000035021

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.17 uM	Inhibition of Mycobacterium tuberculosis thymidine monophosphate kinase by enzyme-coupling based spectrophotometric assay	ChEMBL.	23199481
Ki (binding)	= 0.17 uM	Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysis	ChEMBL.	22061826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1928435

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1562533