Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0342 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0261 | 0.73 | 0.7127 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0342 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0603 | 0.0826 |
Brugia malayi | follicle stimulating hormone receptor | 0.0261 | 0.73 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0603 | 0.0826 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0314 | 0.9057 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0342 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Bmax (binding) | = 0.44 | Bmax value was measured on Abeta40 fibrils | ChEMBL. | 10425090 |
Kd (binding) | = 1.1 uM | Apparent dissociation constant was measured at high salt | ChEMBL. | 10425090 |
logP (ADMET) | = 0.12 | Partition coefficient (logP) | ChEMBL. | 10425090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.