Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome b-245, beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | NADPH oxidase 1 | Starlite/ChEMBL | References |
Homo sapiens | NADPH oxidase 4 | Starlite/ChEMBL | References |
Homo sapiens | NADPH oxidase, EF-hand calcium binding domain 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Loa Loa (eye worm) | blistered cuticle protein 3 | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Onchocerca volvulus | Dual oxidase homolog | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Brugia malayi | Blistered cuticle protein 3 | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | NADPH oxidase, EF-hand calcium binding domain 5 | 737 aa | 730 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.0244 | 1 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Leishmania major | ferric reductase, putative | 0.0151 | 0.3832 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0244 | 1 | 1 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 103 nM | Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 148 nM | Antagonist activity at human NOX1 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 590 nM | Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 1280 nM | Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.