Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0214638 | 0.236953 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.030216 | 0.439378 | 0.932605 |
Loa Loa (eye worm) | thymidylate synthase | 0.0214638 | 0.236953 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.030216 | 0.439378 | 0.932605 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0214638 | 0.236953 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0214638 | 0.236953 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.030216 | 0.439378 | 0.932605 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0315888 | 0.47113 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.030216 | 0.439378 | 1 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0315888 | 0.47113 | 1 |
Schistosoma mansoni | amine GPCR | 0.0544555 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0214638 | 0.236953 | 0.5 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.0315888 | 0.47113 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0214638 | 0.236953 | 0.236953 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.030216 | 0.439378 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.030216 | 0.439378 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0214638 | 0.236953 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0214638 | 0.236953 | 1 |
Onchocerca volvulus | 0.0214638 | 0.236953 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.8 uM | Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting | ChEMBL. | 22285027 |
IC50 (functional) | = 15 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay | ChEMBL. | 22285027 |
IC50 (functional) | = 17 uM | Antiprotozoal activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by alamar blue assay | ChEMBL. | 22285027 |
IC50 (functional) | = 32 uM | Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes infected in rat L6 myoblasts after 96 hrs by CPRG/Nonidet-based spectrophotometry | ChEMBL. | 22285027 |
MIC (functional) | > 220 uM | Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 to 14 days by twofold serial broth dilution method | ChEMBL. | 22285027 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 22285027 | |
Plasmodium falciparum | 22285027 | ||
Trypanosoma brucei gambiense | 22285027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.