Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1142 | 0.4912 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1142 | 0.1142 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0132 | 0.1645 | 0.1645 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1413 | 0.1413 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1413 | 0.1413 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1142 | 0.4912 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0116 | 0.1413 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0116 | 0.1413 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.2326 | 1 |
Giardia lamblia | Ribonuclease H | 0.0116 | 0.1413 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0116 | 0.1413 | 0.1413 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0132 | 0.1645 | 0.1645 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.0586 | 0.2517 |
Toxoplasma gondii | ribonuclease HI protein | 0.0116 | 0.1413 | 0.5 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1413 | 0.6075 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0586 | 0.0586 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.2326 | 0.2326 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.0586 | 0.2517 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0116 | 0.1413 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1142 | 0.4912 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0586 | 0.0586 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0586 | 0.2517 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1413 | 0.6075 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1413 | 0.1413 |
Leishmania major | ribonuclease H1, putative | 0.0116 | 0.1413 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1142 | 0.1142 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1128 | 0.1128 |
Trypanosoma brucei | RNA helicase, putative | 0.072 | 1 | 1 |
Mycobacterium tuberculosis | Possible maturase | 0.0016 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0116 | 0.1413 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0132 | 0.1645 | 0.1645 |
Echinococcus multilocularis | 0.0056 | 0.056 | 0.2407 | |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0116 | 0.1413 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1128 | 0.1128 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0586 | 0.2517 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.2326 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1128 | 0.1128 |
Echinococcus granulosus | ribonuclease H1 | 0.0116 | 0.1413 | 0.6075 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0586 | 0.2517 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1413 | 0.6075 |
Echinococcus multilocularis | ribonuclease H1 | 0.0116 | 0.1413 | 0.6075 |
Trypanosoma brucei | unspecified product | 0.0132 | 0.1645 | 0.1645 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0116 | 0.1413 | 0.3561 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0132 | 0.1645 | 0.1645 |
Onchocerca volvulus | 0.0296 | 0.3968 | 1 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.2326 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.2326 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of recombinant His6-tagged EGFR expressed in baculovirus infected insect Sf9 cells using ATP as substrate and cofactor MgCl2 after 2 hrs by DELFIA/Time-resolved fluorometric analysis | ChEMBL. | 22119130 | |
IC50 (functional) | = 8.8 uM | Antiproliferative activity against mouse B16F10 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
IC50 (functional) | = 15.6 uM | Antiproliferative activity against human MCF7 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
IC50 (functional) | = 29.7 uM | Antiproliferative activity against human A549 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 22119130 | |
Homo sapiens | ChEMBL23 | 22119130 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.