Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0503 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.362 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.362 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.362 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0503 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.362 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0503 | 0.139 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.362 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.362 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.362 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.362 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.362 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 1 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.362 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.362 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.362 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0503 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.362 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 14 % | Induction of apoptosis in human MCF7 cells at 4.1 uM by annexinV-propidium iodide staining-based flow cytometric analysis (Rvb = 11.1%) | ChEMBL. | 22177409 |
GI50 (functional) | = 4.1 uM | Growth inhibition of human MCF7 cells after 48 hrs by SRB assay | ChEMBL. | 22177409 |
GI50 (functional) | = 8.3 uM | Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay | ChEMBL. | 22177409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.