Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.1593 | 0.1534 |
Mycobacterium ulcerans | thymidylate kinase | 0.053 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.053 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.053 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1554 | 0.1494 |
Schistosoma mansoni | tyrosine kinase | 0.0305 | 0.483 | 0.4794 |
Schistosoma mansoni | thymidylate kinase | 0.053 | 1 | 1 |
Plasmodium falciparum | thymidylate kinase | 0.053 | 1 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0164 | 0.1593 | 0.1534 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1554 | 0.1494 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0305 | 0.483 | 0.483 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.053 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0305 | 0.483 | 0.4794 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0164 | 0.1593 | 0.1534 |
Plasmodium vivax | thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.053 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.007 | 0.007 |
Giardia lamblia | CDC8 | 0.053 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.1593 | 0.1534 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0305 | 0.483 | 0.4794 |
Toxoplasma gondii | thymidylate kinase | 0.053 | 1 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.053 | 1 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.053 | 1 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.053 | 1 | 1 |
Echinococcus multilocularis | thymidylate kinase | 0.053 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.053 | 1 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.053 | 1 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1554 | 0.1494 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.007 | 0.007 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0305 | 0.483 | 0.4794 |
Chlamydia trachomatis | thymidylate kinase | 0.053 | 1 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.053 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0164 | 0.1593 | 0.1593 |
Trypanosoma brucei | thymidylate kinase, putative | 0.053 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.053 | 1 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.053 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Binding affinity against endothelin A receptor from rabbit renal vascular smooth muscles | ChEMBL. | 7636842 |
IC50 (binding) | = 6.8 uM | Binding affinity against endothelin B receptor rat cerebellar membranes. | ChEMBL. | 7636842 |
IC50 (functional) | > 10 uM | Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells | ChEMBL. | 7636842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.