Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.037 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.037 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.037 | 0.5 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.037 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.037 | 0.5 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.037 | 0.5 | 0.5 |
Giardia lamblia | CDC8 | 0.037 | 0.5 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.037 | 0.5 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.037 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (binding) | = 7.3 | Binding constant towards tachykinin receptor 1 using ASMSP as agonist on rabbit pulmonary artery tissues. | ChEMBL. | 11591520 |
pKB (binding) | = 7.32 | Binding constant towards Tachykinin receptor 2 using BANK as agonist on rabbit pulmonary artery tissues. | ChEMBL. | 11591520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.