Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.011017 | 0.0729729 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0107887 | 0.0685193 | 0.254153 |
Entamoeba histolytica | iron-containing superoxide dismutase | 0.00918009 | 0.0371419 | 0.5 |
Chlamydia trachomatis | superoxide dismutase | 0.00918009 | 0.0371419 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.011017 | 0.0729729 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0155094 | 0.1606 | 0.298581 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.011017 | 0.0729729 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0155094 | 0.1606 | 0.298581 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0303781 | 0.450625 | 1 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0303781 | 0.450625 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0155094 | 0.1606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00918009 | 0.0371419 | 0.508983 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.0303781 | 0.450625 | 1 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0107887 | 0.0685193 | 0.0758855 |
Echinococcus granulosus | manganese superoxide dismutase | 0.00918009 | 0.0371419 | 0.508983 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0107887 | 0.0685193 | 0.938969 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.00918009 | 0.0371419 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0107887 | 0.0685193 | 0.938969 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0107887 | 0.0685193 | 0.0685193 |
Trichomonas vaginalis | superoxide dismutase, putative | 0.00918009 | 0.0371419 | 0.5 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0107887 | 0.0685193 | 0.0758855 |
Schistosoma mansoni | amine GPCR | 0.0585427 | 1 | 1 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.00918009 | 0.0371419 | 0.508983 |
Echinococcus multilocularis | thymidylate synthase | 0.011017 | 0.0729729 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0107887 | 0.0685193 | 0.938969 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.00918009 | 0.0371419 | 0.5 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.00918009 | 0.0371419 | 0.5 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.00918009 | 0.0371419 | 0.508983 |
Mycobacterium ulcerans | thymidylate synthase | 0.011017 | 0.0729729 | 1 |
Trichomonas vaginalis | superoxide dismutase [mn], putative | 0.00918009 | 0.0371419 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0155094 | 0.1606 | 1 |
Echinococcus multilocularis | manganese superoxide dismutase | 0.00918009 | 0.0371419 | 0.508983 |
Loa Loa (eye worm) | thymidylate synthase | 0.011017 | 0.0729729 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0155094 | 0.1606 | 0.298581 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0107887 | 0.0685193 | 0.254153 |
Trichomonas vaginalis | iron superoxide dismutase A, putative | 0.00918009 | 0.0371419 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0107887 | 0.0685193 | 0.938969 |
Schistosoma mansoni | superoxide dismutase [mn] | 0.00918009 | 0.0371419 | 0.0371419 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0107887 | 0.0685193 | 0.938969 |
Brugia malayi | Superoxide dismutase, mitochondrial precursor, putative | 0.00918009 | 0.0371419 | 0.508983 |
Wolbachia endosymbiont of Brugia malayi | superoxide dismutase, SodA | 0.00918009 | 0.0371419 | 0.5 |
Trichomonas vaginalis | superoxide dismutase, putative | 0.00918009 | 0.0371419 | 0.5 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0107887 | 0.0685193 | 0.0758855 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.011017 | 0.0729729 | 0.0729729 |
Onchocerca volvulus | 0.011017 | 0.0729729 | 1 | |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0107887 | 0.0685193 | 0.254153 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0107887 | 0.0685193 | 0.0758855 |
Brugia malayi | thymidylate synthase | 0.011017 | 0.0729729 | 1 |
Loa Loa (eye worm) | PDE1B protein | 0.0107887 | 0.0685193 | 0.938969 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0155094 | 0.1606 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (ADMET) | = 60.1 % | Cytotoxicity against human NFF assessed as growth inhibition at 100 uM after 3 days by sulforhodamine B assay | ChEMBL. | 22269277 |
IC50 (functional) | = 6.8 uM | Antiplasmodial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter | ChEMBL. | 22269277 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22269277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.