Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0332 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4405 | 0.4405 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0316 | 0.9453 | 0.9453 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0332 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0332 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.087 | 0.5555 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0082 | 0.1566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0036 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0082 | 0.1566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.3828 | 0.3828 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.1566 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0082 | 0.1566 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0082 | 0.1566 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0036 | 0 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0082 | 0.1566 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 94.99 % | Cytotoxicity against human MCF7 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 96.96 % | Cytotoxicity against human UACC62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 102.66 % | Cytotoxicity against human SN12C cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 104.56 % | Cytotoxicity against human HCT116 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 106.99 % | Cytotoxicity against human SF539 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 110.6 % | Cytotoxicity against human HOP62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 112.19 % | Cytotoxicity against human DU145 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 123.43 % | Cytotoxicity against human OVCAR3 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.