Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | No references |
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0451 | 0.2815 | 0.3502 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.063 | 0.4267 | 0.618 |
Brugia malayi | Phospholipase d protein 1 | 0.0124 | 0.0161 | 0.5 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 0.0161 | 1 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0212 | 0.0876 | 0.8682 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0255 | 0.1224 | 0.0568 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0255 | 0.1224 | 0.0568 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.1337 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0886 | 0.6338 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.063 | 0.4267 | 0.618 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.063 | 0.4267 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0161 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.1337 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0451 | 0.2815 | 0.3502 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0161 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0451 | 0.2815 | 0.5229 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0396 | 0.2369 | 0.2678 |
Treponema pallidum | hypothetical protein | 0.0217 | 0.0917 | 1 |
Schistosoma mansoni | phospholipase D | 0.0124 | 0.0161 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 0.0161 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.021 uM | PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 6.5 uM | PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.