Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.5 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.5 | 0.5 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.5 | 0.5 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.5 | 0.5 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.5 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0033 | 0.5 | 0.5 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.5 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.5 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.5 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.5 | 0.5 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | ChEMBL. | 21752655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.