Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0275 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0206 | 0.1741 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0191 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0275 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0206 | 0.1741 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.