Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0119 | 0.0275 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0119 | 0.0549 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 1 |
Brugia malayi | S-adenosyl-methionine cycloartenol-C24-methyltransferase | 0.0272 | 0.4309 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.216 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0119 | 0.0549 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0119 | 0.0549 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0119 | 0.0275 |
Echinococcus granulosus | geminin | 0.0164 | 0.216 | 0.2402 |
Trypanosoma brucei | Sterol methyltransferase, putative | 0.0557 | 1 | 1 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0119 | 0.0132 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0119 | 0.0549 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0119 | 0.0549 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0119 | 0.0275 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0507 | 0.8996 | 1 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0119 | 0.0275 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 0.5 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4309 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.216 | 0.2402 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0119 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.216 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0507 | 0.8996 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0119 | 0.0275 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0119 | 0.0275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.