Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0956 | 0.2019 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 0.1906 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2205 | 0.5496 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0371 | 0.039 | 0.0478 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0675 | 0.1237 | 0.205 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0371 | 0.039 | 0.0254 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0675 | 0.1237 | 0.205 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0281 | 0.0139 | 0.0689 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0675 | 0.1237 | 0.205 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2166 | 0.5389 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0956 | 0.2019 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0956 | 0.2019 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0956 | 0.2019 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0675 | 0.1237 | 0.205 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0956 | 0.2019 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2574 | 0.6523 | 0.6474 |
Schistosoma mansoni | DNA topoisomerase II | 0.0956 | 0.2019 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Giardia lamblia | DNA topoisomerase II | 0.0833 | 0.1676 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1249 | 0.2835 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2205 | 0.5496 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0956 | 0.2019 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2205 | 0.5496 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3823 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3823 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3823 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0371 | 0.039 | 0.0254 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3823 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0956 | 0.2019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.113 | 0.5274 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0956 | 0.2019 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.033 | 0.0276 | 0.073 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0956 | 0.2019 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0956 | 0.2019 | 0.358 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Leishmania major | DNA topoisomerase ii | 0.0675 | 0.1237 | 0.205 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3823 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2205 | 0.5496 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0956 | 0.2019 | 0.1906 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0281 | 0.0139 | 0.0689 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.033 | 0.0276 | 0.073 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 1 |
Schistosoma mansoni | lipoxygenase | 0.033 | 0.0276 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.113 | 0.5274 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3823 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.