Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.5 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | nibrin | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0012 | 0.5 | 0.5 | |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | topbp1 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | DKFZp564C0469 protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | DNA ligase IV | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.5 | 0.5 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | topoisomerase | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0012 | 0.5 | 0.5 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0012 | 0.5 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.0012 | 0.5 | 0.5 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | nibrin | 0.0012 | 0.5 | 0.5 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.5 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | topbp1 | 0.0012 | 0.5 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.0012 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.