Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transcription factor Dp 1 | 0.0262 | 0.5537 | 0.542 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0452 | 1 | 1 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0371 | 0.8108 | 0.8108 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.021 | 0.021 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3414 | 0.3273 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0262 | 0.5537 | 0.542 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0452 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0452 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0452 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0452 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0452 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0255 | 0.0046 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0147 | 0.2852 | 0.2699 |
Onchocerca volvulus | 0.0247 | 0.5204 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0171 | 0.3414 | 0.3242 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0583 | 0.0583 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0255 | 0.0255 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0452 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0583 | 0.0583 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0452 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0255 | 0.0046 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0377 | 0.824 | 0.8194 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0377 | 0.824 | 0.8194 |
Echinococcus granulosus | geminin | 0.0171 | 0.3414 | 0.3242 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 0.5204 | 0.5101 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.5204 | 0.5204 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3414 | 0.3273 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0377 | 0.824 | 0.824 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0583 | 0.0583 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0583 | 0.0583 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0452 | 1 | 1 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0247 | 0.5204 | 0.5204 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.01 | 0.1756 | 0.1579 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.5204 | 0.5079 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0366 | 0.7982 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.64 uM | Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation counting | ChEMBL. | 20504026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.