Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 94 nM | Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 to 24 hrs by ELISA | ChEMBL. | 21963986 |
Efficacy (functional) | = 84 % | Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs relative to Dexamethasone | ChEMBL. | 21963986 |
Efficacy (binding) | = 98 % | Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 to 24 hrs by ELISA relative to Dexamethasone | ChEMBL. | 21963986 |
IC50 (binding) | = 24 nM | Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant glucocorticoid receptor expressed in baculovirus infected insect cells by fluorescence polarization assay | ChEMBL. | 21963986 |
IC50 (functional) | = 78 nM | Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs | ChEMBL. | 21963986 |
IC50 (binding) | = 405 nM | Displacement of tetramethylrhodamine-labeled RU-486 from human recombinant progesterone receptor expressed in baculovirus infected insect cells by fluorescence polarization assay | ChEMBL. | 21963986 |
IC50 (binding) | = 405 nM | Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant mineralocorticoid receptor expressed in baculovirus infected insect cells by fluorescence polarization assay | ChEMBL. | 21963986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.