Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0483 | 1 | 0.5 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0483 | 1 | 0.5 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0483 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) | 0.0246 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0483 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0483 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0483 | 1 | 0.5 |
Plasmodium falciparum | porphobilinogen synthase | 0.0483 | 1 | 0.5 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0483 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0483 | 1 | 0.5 |
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0483 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 5.32 uM | Antimicrobial activity against replicating Mycobacterium tuberculosis after 8 days by micro plate alamar blue assay | ChEMBL. | 21903392 |
MIC90 (functional) | > 21.7 uM | Antimicrobial activity against non-replicating Mycobacterium tuberculosis after 11 days by luminescence based low oxygen recovery assay | ChEMBL. | 21903392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.