Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 31 uM | Antiproliferative activity against human HeLa cells after 2 days by coulter counter analysis | ChEMBL. | 22027100 |
IC50 (functional) | = 32 uM | Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter analysis | ChEMBL. | 22027100 |
IC50 (functional) | = 42 uM | Antiproliferative activity against human CEM cells after 2 days by coulter counter analysis | ChEMBL. | 22027100 |
IC50 (functional) | = 47 uM | Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter analysis | ChEMBL. | 22027100 |
IC50 (functional) | = 53 uM | Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter analysis | ChEMBL. | 22027100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.