Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0054 | 0.1129 | 0.1129 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0045 | 0.0077 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0125 | 1 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0045 | 0.0077 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0062 | 0.2202 | 0.2202 |
Plasmodium falciparum | glutathione reductase | 0.0125 | 1 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0125 | 1 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0045 | 0.0077 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0071 | 0.333 | 0.333 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0063 | 0.2278 | 0.2278 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0062 | 0.2202 | 0.2202 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0071 | 0.333 | 0.333 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0063 | 0.2278 | 0.2278 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0071 | 0.333 | 0.333 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0125 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0054 | 0.1129 | 0.1129 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0125 | 1 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0045 | 0.0077 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0062 | 0.2202 | 0.2202 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0062 | 0.2202 | 0.2202 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0045 | 0.0077 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0063 | 0.2278 | 0.2278 |
Trypanosoma brucei | trypanothione reductase | 0.0125 | 1 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0125 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0071 | 0.333 | 0.333 |
Plasmodium falciparum | thioredoxin reductase | 0.0125 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.