Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinesin eg-5 | 0.0162 | 0.1164 | 0.1341 |
Giardia lamblia | Kinesin-5 | 0.0162 | 0.1164 | 1 |
Plasmodium vivax | kinesin-5 | 0.0162 | 0.1164 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1088 | 0.8681 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0368 | 0.0424 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0368 | 0.3162 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0368 | 0.3162 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0162 | 0.1164 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0368 | 0.0424 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0368 | 0.0424 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0368 | 0.3162 |
Entamoeba histolytica | kinesin, putative | 0.0162 | 0.1164 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0368 | 0.3162 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0368 | 0.0424 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0162 | 0.1164 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1251 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0368 | 0.3162 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0368 | 0.0424 |
Brugia malayi | Kinesin motor domain containing protein | 0.0162 | 0.1164 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0368 | 0.3162 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0162 | 0.1164 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0368 | 0.0368 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0368 | 0.0368 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.