Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0138 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0138 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0138 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0096 | 0.5661 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0138 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0138 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0138 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0138 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0138 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0138 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0138 | 1 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0138 | 1 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0138 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0138 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0138 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0138 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0109 | 0.6979 | 0.5671 |
Plasmodium falciparum | pyruvate kinase | 0.0138 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0138 | 1 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0138 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0138 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0138 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0138 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0138 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0138 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0138 | 1 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0138 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0138 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0138 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.