Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0081 | 1 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0081 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.5895 | 0.5895 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.5895 | 0.5895 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0081 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.5895 | 0.5895 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2122 | 0.2122 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Brugia malayi | Trypsin family protein | 0.0081 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0081 | 1 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0081 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0081 | 1 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0081 | 1 | 0.5 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0081 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.5895 | 0.5895 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0081 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0081 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2122 | 0.2122 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.