Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | No references |
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0043 | 0.0317 | 0.0175 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0144 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0166 | 0.4685 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.3203 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0043 | 0.0317 | 0.0564 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0144 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5071 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.4085 | 0.3999 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0315 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.011 | 0.2686 | 0.516 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0149 | 0.4085 | 0.3999 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.035 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1658 | 0.6441 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2494 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0315 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5071 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.3203 | 1 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0043 | 0.0317 | 0.3943 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0144 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0695 | 0.0559 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.4685 | 1 |
Trypanosoma brucei | cardiolipin synthetase | 0.0043 | 0.0317 | 0.0175 |
Entamoeba histolytica | phospholipase D active site domain-containing protein | 0.0104 | 0.2494 | 0.768 |
Echinococcus granulosus | phospholipase D | 0.011 | 0.2686 | 0.516 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1658 | 0.6441 |
Schistosoma mansoni | phospholipase D | 0.0124 | 0.3203 | 0.621 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.4085 | 0.3999 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.035 | 0.0209 |
Brugia malayi | Phospholipase d protein 1 | 0.0124 | 0.3203 | 1 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 0.3203 | 0.621 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2494 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0144 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.035 | 0.0209 |
Echinococcus granulosus | geminin | 0.0177 | 0.5071 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0315 | 1 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.0317 | 0.0175 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.0317 | 0.0175 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0177 | 0.5071 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0.0582 | 1 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 0.3203 | 0.621 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.035 | 0.0209 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.004 uM | PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 0.34 uM | PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.