Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3823 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3823 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3823 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2205 | 0.5496 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0833 | 0.1676 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Schistosoma mansoni | DNA topoisomerase II | 0.0956 | 0.2019 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2205 | 0.5496 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0956 | 0.2019 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1249 | 0.2835 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.033 | 0.0276 | 0.073 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0281 | 0.0139 | 0.0689 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0956 | 0.2019 | 0.1906 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2205 | 0.5496 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.113 | 0.5274 |
Schistosoma mansoni | lipoxygenase | 0.033 | 0.0276 | 0.1369 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3823 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0956 | 0.2019 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0956 | 0.2019 | 0.358 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.033 | 0.0276 | 0.073 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0956 | 0.2019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.113 | 0.5274 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0956 | 0.2019 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3823 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0371 | 0.039 | 0.0254 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3823 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0371 | 0.039 | 0.0254 |
Leishmania major | DNA topoisomerase ii | 0.0675 | 0.1237 | 0.205 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0675 | 0.1237 | 0.205 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0371 | 0.039 | 0.0254 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0956 | 0.2019 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0371 | 0.039 | 0.0478 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2205 | 0.5496 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0956 | 0.2019 | 0.1906 |
Brugia malayi | Probable DNA topoisomerase II | 0.0956 | 0.2019 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0956 | 0.2019 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2574 | 0.6523 | 0.6474 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0956 | 0.2019 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0956 | 0.2019 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0675 | 0.1237 | 0.205 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0675 | 0.1237 | 0.205 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0281 | 0.0139 | 0.0689 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2166 | 0.5389 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0675 | 0.1237 | 0.205 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.