Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.1396 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0523 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.1396 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.1396 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1396 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.1396 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.1396 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1396 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.1396 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0523 | 0.3463 | 0.3463 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0523 | 0.3463 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1396 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.0523 | 0.3463 | 0.3463 |
Echinococcus multilocularis | histone deacetylase 1 | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1396 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.1396 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0523 | 0.3463 | 0.3463 |
Leishmania major | histone deacetylase, putative | 0.1396 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.1396 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.1396 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.1396 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0523 | 0.3463 | 0.3463 |
Schistosoma mansoni | histone deacetylase | 0.1396 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0523 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | hypothetical protein | 0.1396 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1396 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.1396 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1396 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.