Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.0268 | 1 | 1 |
Brugia malayi | Fibroblast growth factor family protein | 0.0134 | 0.4314 | 0.4314 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0663 | 0.0663 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0663 | 0.0663 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0134 | 0.4314 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4314 | 0.4314 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4314 | 0.4314 |
Brugia malayi | Fibroblast growth factor family protein | 0.0134 | 0.4314 | 0.4314 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.