Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5595 | 0.8998 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1829 | 0.3269 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1829 | 0.2941 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5595 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1829 | 0.2941 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1829 | 0.3269 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.6218 | 0.6218 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1829 | 0.2941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5595 | 0.8998 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5595 | 0.5595 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5595 | 0.5595 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1829 | 0.3269 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1829 | 0.1829 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1829 | 0.1829 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1829 | 0.3269 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5595 | 0.5595 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.6218 | 0.6218 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5595 | 0.8998 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1829 | 0.1829 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.6218 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1829 | 0.1829 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1829 | 0.3269 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1829 | 0.3269 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1829 | 0.2941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5595 | 0.8998 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5595 | 0.5595 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5595 | 0.8998 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5595 | 0.5595 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5595 | 0.5595 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Mean survival time (functional) | = 5.4 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 20 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 5.4 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 20 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 6 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 40 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 6 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 40 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 7.2 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 80 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 7.2 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 80 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 8 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 160 mg/kg. | ChEMBL. | 1895301 |
Mean survival time (functional) | = 8 day | In vivo antimalarial activity against Plasmodium berghei expressed as mean survival time of mice at a dose of 160 mg/kg. | ChEMBL. | 1895301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.