Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone deacetylase 8 | 0.0153 | 0.0295 | 0.342 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0052 | 0.0045 | 0.0172 |
Leishmania major | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0296 | 0.0647 | 0.7406 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0052 | 0.0045 | 0.0521 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0052 | 0.0045 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0012 | 0.0144 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0308 | 0.0678 | 0.7862 |
Echinococcus granulosus | histone deacetylase 6 | 0.0296 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 8 | 0.0153 | 0.0295 | 0.342 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0153 | 0.0295 | 0.3178 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0039 | 0.0012 | 0.0144 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0383 | 0.0863 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0296 | 0.0647 | 0.7498 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Echinococcus granulosus | histone deacetylase 6 | 0.0308 | 0.0678 | 0.7862 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0296 | 0.0647 | 0.7498 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.005 | 0.004 | 0.0118 |
Echinococcus granulosus | disco interacting protein 2 | 0.0039 | 0.0012 | 0.0144 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0296 | 0.0647 | 0.7406 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.03 | 0.3482 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0085 | 0.0126 | 0.115 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0383 | 0.0863 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0153 | 0.0295 | 0.342 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0383 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0052 | 0.0045 | 0.0172 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0296 | 0.0647 | 0.7498 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0383 | 0.0863 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0383 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0052 | 0.0045 | 0.0172 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0296 | 0.0647 | 0.7406 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.005 | 0.004 | 0.0118 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0153 | 0.0295 | 0.3178 |
Loa Loa (eye worm) | histone deacetylase | 0.0296 | 0.0647 | 0.7498 |
Entamoeba histolytica | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0052 | 0.0045 | 0.0521 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0039 | 0.0012 | 0.0144 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0296 | 0.0647 | 0.7498 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.0046 | 0.0031 | 0.0355 |
Echinococcus granulosus | histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0296 | 0.0647 | 0.7498 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0383 | 0.0863 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.005 | 0.004 | 0.0118 |
Giardia lamblia | Histone deacetylase | 0.0383 | 0.0863 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0153 | 0.0295 | 0.3178 |
Echinococcus granulosus | histone deacetylase | 0.0296 | 0.0647 | 0.7498 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0383 | 0.0863 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0153 | 0.0295 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0383 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0383 | 0.0863 | 1 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0052 | 0.0045 | 0.0521 |
Schistosoma mansoni | histone deacetylase | 0.0383 | 0.0863 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0153 | 0.0295 | 0.342 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0296 | 0.0647 | 0.7498 |
Plasmodium falciparum | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Onchocerca volvulus | 0.0039 | 0.0012 | 0.042 | |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0052 | 0.0045 | 0.0172 |
Plasmodium vivax | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Leishmania major | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Echinococcus granulosus | histone deacetylase 6 | 0.0296 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 7 | 0.0296 | 0.0647 | 0.7498 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0383 | 0.0863 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0052 | 0.0045 | 0.0172 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0052 | 0.0045 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.0863 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0085 | 0.0126 | 0.115 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0052 | 0.0045 | 0.0521 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.4038 | 0.9887 | 1 |
Leishmania major | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Trypanosoma brucei | histone deacetylase 4 | 0.0296 | 0.0647 | 0.7406 |
Trypanosoma brucei | histone deacetylase 2 | 0.0153 | 0.0295 | 0.3178 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.0046 | 0.0031 | 0.0355 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.4084 | 1 | 1 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0052 | 0.0045 | 0.0172 |
Leishmania major | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0296 | 0.0647 | 0.7498 |
Trypanosoma brucei | histone deacetylase, putative | 0.0296 | 0.0647 | 0.7406 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0308 | 0.0678 | 0.7862 |
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.0046 | 0.0031 | 0.0355 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0039 | 0.0012 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0269 | 0.3119 |
Brugia malayi | histone deacetylase 11 | 0.0153 | 0.0295 | 0.342 |
Plasmodium falciparum | histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.0046 | 0.0031 | 0.0355 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.0046 | 0.0031 | 0.0355 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0383 | 0.0863 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0296 | 0.0647 | 0.7406 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0153 | 0.0295 | 0.3178 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0153 | 0.0295 | 0.3178 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0295 | 0.342 |
Brugia malayi | Histone deacetylase family protein | 0.0296 | 0.0647 | 0.7498 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0383 | 0.0863 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0383 | 0.0863 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0383 | 0.0863 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0153 | 0.0295 | 0.342 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0296 | 0.0647 | 0.7498 |
Brugia malayi | Histone deacetylase 1 | 0.0383 | 0.0863 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0383 | 0.0863 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.