Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.0046 | 0.0031 | 0.0355 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0306 | 0.0678 | 0.7861 |
Trypanosoma brucei | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Plasmodium falciparum | histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.0046 | 0.0031 | 0.0355 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.0046 | 0.0031 | 0.0355 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0038 | 0.0012 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0269 | 0.3119 |
Brugia malayi | histone deacetylase 11 | 0.0152 | 0.0295 | 0.342 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0172 |
Echinococcus multilocularis | histone deacetylase | 0.0293 | 0.0647 | 0.7498 |
Leishmania major | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0293 | 0.0647 | 0.7498 |
Schistosoma mansoni | histone deacetylase | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.038 | 0.0863 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0152 | 0.0295 | 0.342 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.038 | 0.0863 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.038 | 0.0863 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0152 | 0.0295 | 0.3178 |
Plasmodium falciparum | histone deacetylase 2 | 0.0293 | 0.0647 | 0.7406 |
Echinococcus multilocularis | histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0295 | 0.342 |
Brugia malayi | Histone deacetylase family protein | 0.0293 | 0.0647 | 0.7498 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0152 | 0.0295 | 0.3178 |
Plasmodium vivax | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0172 |
Echinococcus granulosus | histone deacetylase 7 | 0.0293 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 6 | 0.0293 | 0.0647 | 0.7498 |
Leishmania major | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0172 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0152 | 0.0295 | 0.342 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0293 | 0.0647 | 0.7498 |
Schistosoma mansoni | histone deacetylase | 0.038 | 0.0863 | 1 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0051 | 0.0045 | 0.0521 |
Onchocerca volvulus | 0.0038 | 0.0012 | 0.042 | |
Plasmodium falciparum | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.0046 | 0.0031 | 0.0355 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.0152 | 0.0295 | 0.3178 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.4048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0051 | 0.0045 | 0.0172 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Leishmania major | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Trypanosoma brucei | histone deacetylase 4 | 0.0293 | 0.0647 | 0.7406 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 0.0126 | 0.115 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0051 | 0.0045 | 0.0521 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.4002 | 0.9887 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0152 | 0.0295 | 0.3178 |
Loa Loa (eye worm) | histone deacetylase | 0.0293 | 0.0647 | 0.7498 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0293 | 0.0647 | 0.7498 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0038 | 0.0012 | 0.0144 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.0046 | 0.0031 | 0.0355 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0051 | 0.0045 | 0.0521 |
Entamoeba histolytica | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0051 | 0.0045 | 0.0172 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0293 | 0.0647 | 0.7498 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.038 | 0.0863 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0293 | 0.0647 | 0.7406 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0049 | 0.004 | 0.0118 |
Trichomonas vaginalis | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0051 | 0.0045 | 0.0172 |
Plasmodium vivax | histone deacetylase, putative | 0.0152 | 0.0295 | 0.3178 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.038 | 0.0863 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0293 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 3 | 0.038 | 0.0863 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.038 | 0.0863 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0152 | 0.0295 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0293 | 0.0647 | 0.7498 |
Echinococcus multilocularis | histone deacetylase 3 | 0.038 | 0.0863 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.038 | 0.0863 | 1 |
Giardia lamblia | Histone deacetylase | 0.038 | 0.0863 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0049 | 0.004 | 0.0118 |
Echinococcus granulosus | histone deacetylase 6 | 0.0293 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 8 | 0.0152 | 0.0295 | 0.342 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0012 | 0.0144 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0051 | 0.0045 | 0.0521 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0051 | 0.0045 | 0.0521 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0306 | 0.0678 | 0.7861 |
Brugia malayi | Histone deacetylase family protein | 0.0293 | 0.0647 | 0.7498 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0038 | 0.0012 | 0.0144 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0152 | 0.0295 | 0.3178 |
Leishmania major | histone deacetylase, putative | 0.038 | 0.0863 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0051 | 0.0045 | 0.0172 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0152 | 0.0295 | 0.342 |
Trypanosoma brucei | histone deacetylase 3 | 0.0293 | 0.0647 | 0.7406 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0084 | 0.0126 | 0.115 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.038 | 0.0863 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0152 | 0.0295 | 0.342 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0293 | 0.0647 | 0.7406 |
Echinococcus granulosus | disco interacting protein 2 | 0.0038 | 0.0012 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.03 | 0.3482 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.038 | 0.0863 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0293 | 0.0647 | 0.7406 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0293 | 0.0647 | 0.7498 |
Echinococcus granulosus | histone deacetylase 6 | 0.0306 | 0.0678 | 0.7861 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0049 | 0.004 | 0.0118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.