Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0103 | 0.0112 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0298 | 0.3962 | 0.4971 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0726 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0405 | 0.5472 | 0.6874 |
Mycobacterium ulcerans | hypothetical protein | 0.0243 | 0.3182 | 0.399 |
Chlamydia trachomatis | PTS system PEP phosphotransferase | 0.0243 | 0.3182 | 0.399 |
Brugia malayi | pyruvate kinase | 0.0122 | 0.148 | 0.1753 |
Echinococcus multilocularis | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Leishmania major | pyruvate phosphate dikinase, putative | 0.0243 | 0.3182 | 0.3922 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0581 | 0.7954 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0405 | 0.5472 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0581 | 0.7954 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0581 | 0.7954 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0103 | 0.0112 |
Echinococcus multilocularis | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Echinococcus granulosus | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0103 | 0.0112 |
Mycobacterium ulcerans | pyruvate phosphate dikinase | 0.0243 | 0.3182 | 0.399 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0103 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0103 | 0.0112 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0103 | 0.0112 |
Mycobacterium leprae | PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK | 0.0243 | 0.3182 | 0.3922 |
Mycobacterium ulcerans | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Leishmania major | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0581 | 0.7954 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Entamoeba histolytica | pyruvate phosphate dikinase | 0.0243 | 0.3182 | 0.5735 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0243 | 0.3182 | 0.4001 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0581 | 0.7954 | 1 |
Treponema pallidum | pyruvate phosphate dikinase | 0.0243 | 0.3182 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0581 | 0.7954 | 1 |
Wolbachia endosymbiont of Brugia malayi | pyruvate phosphate dikinase | 0.0243 | 0.3182 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0103 | 0.0112 |
Plasmodium vivax | pyruvate kinase, putative | 0.0581 | 0.7954 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0581 | 0.7954 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0103 | 0.0112 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0014 | 0.0018 |
Giardia lamblia | Pyruvate kinase | 0.0298 | 0.3962 | 0.1633 |
Echinococcus granulosus | pyruvate kinase | 0.0581 | 0.7954 | 0.6612 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0581 | 0.7954 | 1 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0298 | 0.3962 | 0.4971 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0103 | 0.013 |
Loa Loa (eye worm) | pyruvate kinase | 0.0122 | 0.148 | 0.1845 |
Giardia lamblia | Pyruvate kinase | 0.0581 | 0.7954 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0103 | 0.0112 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0726 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0103 | 0.013 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0103 | 0.0112 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0581 | 0.7954 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0176 | 0.2233 | 0.2713 |
Mycobacterium tuberculosis | Probable pyruvate, phosphate dikinase PpdK | 0.0243 | 0.3182 | 0.4001 |
Loa Loa (eye worm) | hypothetical protein | 0.0581 | 0.7954 | 1 |
Leishmania major | pyruvate kinase | 0.0581 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.5472 | 0.6874 |
Echinococcus multilocularis | pyruvate kinase | 0.0459 | 0.6226 | 0.375 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0122 | 0.148 | 0.1753 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0103 | 0.0112 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.616 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.252 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.029 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.998 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.713 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.666 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.606 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.552 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.328 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.253 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.