Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldo-keto reductase-like protein | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldehyde reductase | 0.0165 | 0.082 | 0.0943 |
Echinococcus multilocularis | aldo keto reductase | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0165 | 0.082 | 0.0943 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0232 | 0.869 | 1 |
Giardia lamblia | Aldose reductase | 0.0232 | 0.869 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0232 | 0.869 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0232 | 0.869 | 1 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0232 | 0.869 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0232 | 0.869 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | geminin | 0.0179 | 0.2499 | 0.2876 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0232 | 0.869 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus granulosus | geminin | 0.0179 | 0.2499 | 0.2876 |
Entamoeba histolytica | aldose reductase, putative | 0.0232 | 0.869 | 0.5 |
Schistosoma mansoni | pol-related | 0.0232 | 0.869 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0232 | 0.869 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0232 | 0.869 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0232 | 0.869 | 0.5 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0232 | 0.869 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0232 | 0.869 | 1 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0232 | 0.869 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0232 | 0.869 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0232 | 0.869 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0232 | 0.869 | 0.5 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.869 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0232 | 0.869 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0232 | 0.869 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Onchocerca volvulus | 0.0232 | 0.869 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0232 | 0.869 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0232 | 0.869 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0232 | 0.869 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.034 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.006 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.718 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.401 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.22 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.