Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0455 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0455 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2789 | 0.2789 |
Onchocerca volvulus | Deterin homolog | 0.0455 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0167 | 0.2789 | 0.2789 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0455 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.6159 | 0.6159 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.6159 | 0.6159 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.6159 | 0.6159 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 1 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0301 | 0.6159 | 0.4673 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0455 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0455 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0455 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0455 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0301 | 0.6159 | 0.6159 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0455 | 1 | 1 |
Onchocerca volvulus | 0.0301 | 0.6159 | 0.4673 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.