Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Catechol O-methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | O-methyltransferase | Get druggable targets OG5_131164 | All targets in OG5_131164 |
Candida albicans | hypothetical protein | Get druggable targets OG5_131164 | All targets in OG5_131164 |
Candida albicans | potential catechol-O-methyltransferase | Get druggable targets OG5_131164 | All targets in OG5_131164 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | Get druggable targets OG5_131164 | All targets in OG5_131164 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0371 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0371 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0625 | 0.6007 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0371 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0371 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0371 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0371 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0371 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0371 | 0 | 0.5 |
Mycobacterium ulcerans | O-methyltransferase | 0.0697 | 0.7722 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0371 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0371 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.692 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.684 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.614 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.516 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.505 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.481 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.433 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.299 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 5.56 | Inhibition of Sprague-Dawley rat liver COMT after 10 mins using 0.05 uCi [14CH3]-SAM as substrate | ChEMBL. | 817025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.