Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.2523 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.2523 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0144 | 0.2523 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.2523 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0144 | 0.2523 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0422 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0422 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0144 | 0.2523 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0144 | 0.2523 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0144 | 0.2523 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0422 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0422 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0051 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0144 | 0.2523 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0422 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0144 | 0.2523 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0144 | 0.2523 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0144 | 0.2523 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.2523 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.2523 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0144 | 0.2523 | 0.5 |
Schistosoma mansoni | amidase | 0.0422 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.2523 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0144 | 0.2523 | 1 |
Plasmodium vivax | PST-A protein | 0.0144 | 0.2523 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0144 | 0.2523 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0144 | 0.2523 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.2523 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0144 | 0.2523 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0144 | 0.2523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.362 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.535 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.225 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.211 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.