Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | No references | |
Mus musculus | prostaglandin-endoperoxide synthase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | 0.0111 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | 0.0111 | 1 | 0.5 | |
Onchocerca volvulus | 0.0111 | 1 | 0.5 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0111 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 1 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0088 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0111 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0111 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0111 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0111 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 nM | In Vitro Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.027 uM | Inhibition of COX2 in Escherichia coli LPS-stimulated mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay | PATENT. | No reference |
IC50 (binding) | = 0.096 uM | Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassay | ChEMBL. | 21992176 |
IC50 (binding) | > 10 uM | Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challenge by radioimmunoassay | ChEMBL. | 21992176 |
Inhibition (binding) | < 20 % | Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay relative to control | PATENT. | No reference |
Inhibition (binding) | = 22 % | Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells at 10 uM incubated for 15 mins prior to arachidonic acid-challenge by radioimmunoassay | ChEMBL. | 21992176 |
Inhibition (binding) | = 51 % | Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells at 0.1 uM after 24 hrs by radioimmunoassay | ChEMBL. | 21992176 |
Inhibition (binding) | = 92 % | Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells at 1 uM after 24 hrs by radioimmunoassay | ChEMBL. | 21992176 |
Inhibition (binding) | = 100 % | Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells at 10 uM after 24 hrs by radioimmunoassay | ChEMBL. | 21992176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.